Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Wnts are secreted proteins that bind to cell surface receptors to activate downstream
signaling cascades. Normal Wnt signaling plays key roles in embryonic development and …

Abstract Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the
cellular machinery that executes “programmed” or “regulated” necrosis. Here we show that …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Studies over the past four decades have elucidated the role of Wnt/β-catenin mediated
regulation in cell proliferation, differentiation and migration. These processes are …

WNT signaling is crucial for tissue morphogenesis during development in all multicellular
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …

Both appropriate DNA methylation and histone modifications play a crucial role in the
maintenance of normal cell function and cellular identity. In cancerous cells these …

Aberrant activation of the WNT/ß-catenin signaling pathway is frequently involved in a broad
spectrum of human malignancies. Alternative to genetic deletions and point mutations …

The Wnt (wingless-type) signaling pathway plays an important role in embryonic
development, tissue homeostasis, and tumor progression becaluse of its effect on cell …

Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve
prognosis and treatment of advanced cancer patients. In this study, we performed a genome …