A role for local inflammation in the formation of drusen in the aging eye
DH Anderson, RF Mullins, GS Hageman… - American journal of …, 2002 - Elsevier
PURPOSE: The accumulation of numerous or confluent drusen, especially in the macula, is
a significant risk factor for the development of age-related macular degeneration (AMD) …
a significant risk factor for the development of age-related macular degeneration (AMD) …
Noncellular nonspecific defence mechanisms of fish
JB Alexander, GA Ingram - Annual Review of Fish Diseases, 1992 - Elsevier
Fish tissues and body fluids contain naturally occurring proteins or glycoproteins of non-
immunoglobulin (Ig) nature that react with a diverse array of environmental antigens and …
immunoglobulin (Ig) nature that react with a diverse array of environmental antigens and …
Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune …
JHC Wong, JYW Ma, AI Jobling, A Brandli… - Frontiers in …, 2022 - frontiersin.org
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in the
older population. Classical hallmarks of early and intermediate AMD are accumulation of …
older population. Classical hallmarks of early and intermediate AMD are accumulation of …
Acute anterior uveitis and HLA-B27
JH Chang, PJ McCluskey, D Wakefield - Survey of ophthalmology, 2005 - Elsevier
Acute anterior uveitis is the most common form of uveitis. HLA-B27-associated acute anterior
uveitis is a distinct clinical entity that has wide-ranging medical significance due to its ocular …
uveitis is a distinct clinical entity that has wide-ranging medical significance due to its ocular …
Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes
GM Holtkamp, A Kijlstra, R Peek, AF De Vos - Progress in retinal and eye …, 2001 - Elsevier
Vision is dependent on proper function of several intraocular structures. Immune responses
to eliminate invading pathogens from the eye may threat vision by causing damage to these …
to eliminate invading pathogens from the eye may threat vision by causing damage to these …
Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD
PV Algvere, P Gouras… - European journal of …, 1999 - journals.sagepub.com
Purpose To determine the long-term outcome of human retinal pigment epithelium (RPE)
transplants in patients with advanced age-related macular degeneration (AMD). Methods …
transplants in patients with advanced age-related macular degeneration (AMD). Methods …
Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments
Complement activation is thought to be involved in the pathogenesis of age-related macular
degeneration (AMD), in part because certain gene polymorphisms in complement factor H …
degeneration (AMD), in part because certain gene polymorphisms in complement factor H …
Good news–bad news: the Yin and Yang of immune privilege in the eye
JV Forrester, H Xu - Frontiers in immunology, 2012 - frontiersin.org
The eye and the brain are prototypical tissues manifesting immune privilege (IP) in which
immune responses to foreign antigens, particularly alloantigens are suppressed, and even …
immune responses to foreign antigens, particularly alloantigens are suppressed, and even …
Immunopathology of scleritis
LP Fong, MS de la Maza, BA Rice, AE Kupferman… - Ophthalmology, 1991 - Elsevier
Conjunctival and scleral biopsies from 25 patients with necrotizing scleritis and 5 patients
with recurrent nonnecrotizing scleritis were studied by histopathologic, immunofluorescence …
with recurrent nonnecrotizing scleritis were studied by histopathologic, immunofluorescence …
Polarized secretion of IL-6 and IL-8 by human retinal pigment epithelial cells
GM Holtkamp, M Van Rossem… - Clinical & …, 1998 - academic.oup.com
SUMMARY A number of cell types situated along interfaces of various tissues and organs
such as the peritoneum and the intestine have been shown to secrete inflammatory …
such as the peritoneum and the intestine have been shown to secrete inflammatory …