Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is
believed to affect> 25% of adults worldwide. Unless specific testing is done to identify …

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …

Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

Current paradigms of cancer-centric therapeutics are usually not sufficient to eradicate the
malignancy, as the cancer stroma may prompt tumour relapse and therapeutic resistance …

The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …