A biomarker is defined as an objectively measured characteristic of a normal or pathologic
biologic process. Identification and proper validation of biomarkers of epileptogenesis (the …

Children with epilepsy and normal structural MRI pose a particular challenge in localization
of epileptic foci for surgical resection. Many of these patients have subtle structural lesions …

Background: Activation of central serotonin (5-HT) 1A receptors, found in high density in
brainstem raphe, hippocampus, and temporal neocortex, exerts an anticonvulsant effect in …

The aim of our study was to assess abnormalities in 5‐hydroxytryptamine‐1A (5‐HT1A)
receptor density in patients suffering from refractory temporal lobe epilepsy (TLE) …

Frontal lobe epilepsy accounts for only 10‐20% of the patients in surgical series, but the
incidence in non‐surgical patient cohorts seems to be much higher. The typical clinical …

Over the past decade there have been many advances in data acquisition and analysis for
structural and functional neuroimaging of people with epilepsy. New imaging sequences …

Background: In children with tuberous sclerosis, the PET tracer α [11C] methyl-l-tryptophan
(AMT) has been shown to be selectively taken up by epileptogenic tubers, thus allowing …

Over the past 35 years or so, PET brain imaging has allowed powerful and unique insights
into brain function under normal conditions and in disease states. Initially, as PET …

Serotonergic abnormalities have been reported in both autism and epilepsy. This
association may provide insights into underlying mechanisms of these disorders because …

Subdural electrodes are frequently used to aid in the neurophysiological assessment of
patients with intractable seizures. We review the indications for these, their uses for …