Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs)
are tremendous, the design and discovery of new candidates remain a time and cost …

There is considerable interest in the pharmaceutical industry toward development of
antibody-based biotherapeutics because they can selectively bind diverse receptors and …

Amyloid proteins have the ability to form insoluble fibril aggregates that have important
pathogenic effects in many tissues. Such amyloidoses are prominently associated with …

Therapeutic protein, represented by antibodies, is of increasing interest in human medicine.
However, clinical translation of therapeutic protein is still largely hindered by different …

There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …

Similar to other polypeptides and electrolytes, proteins undergo phase transitions, obeying
physicochemical laws. They can undergo liquid-to-gel and liquid-to-liquid phase transitions …

Molecular encodings and their usage in machine learning models have demonstrated
significant breakthroughs in biomedical applications, particularly in the classification of …

Recombinant multiepitope proteins (RMPs) are a promising alternative for application in
diagnostic tests and, given their wide application in the most diverse diseases, this review …

The UNited RESidue (UNRES) model of polypeptide chains was applied to study the
association of 20 peptides with sizes ranging from 6 to 32 amino-acid residues. Twelve of …

Hsp70 molecular chaperones play central roles in maintaining a healthy cellular proteome.
Hsp70s function by binding to short peptide sequences in incompletely folded client …