The evasion mechanisms of cancer immunity and drug intervention in the tumor microenvironment

SK Kim, SW Cho - Frontiers in pharmacology, 2022 - frontiersin.org
Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that
activates the immune system to induce cancer attacks. Among them, immune checkpoint …

Chemokines in triple-negative breast cancer heterogeneity: new challenges for clinical implications

U Mehraj, U Mushtaq, MA Mir, A Saleem… - Seminars in Cancer …, 2022 - Elsevier
Tumor heterogeneity is a hallmark of cancer and one of the primary causes of resistance to
therapies. Triple-negative breast cancer (TNBC), which accounts for 15–20% of all breast …

The FUS/circEZH2/KLF5/feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

P Liu, Z Wang, X Ou, P Wu, Y Zhang, S Wu, X Xiao… - Molecular cancer, 2022 - Springer
Background Metastasis of breast cancer have caused the majority of cancer-related death
worldwide. The circRNAs are associated with tumorigenesis and metastasis in breast cancer …

LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression

T Sun, Z Wu, X Wang, Y Wang, X Hu, W Qin, S Lu, D Xu… - Oncogene, 2020 - nature.com
Increasing evidence supports that long noncoding RNAs (lncRNAs) act as master regulators
involved in tumorigenesis and development at the N 6-methyladenine (m6A) epigenetic …

The signaling duo CXCL12 and CXCR4: chemokine fuel for breast cancer tumorigenesis

KA Zielińska, VL Katanaev - Cancers, 2020 - mdpi.com
Simple Summary Breast cancer remains the most common malignancy in women. In this
review, we explore the role of the CXCL12/CXCR4 pathway in breast cancer. We show that …

Effects of novel SGLT2 inhibitors on cancer incidence in hyperglycemic patients: a meta-analysis of randomized clinical trials

R Benedetti, G Benincasa, K Glass, U Chianese… - Pharmacological …, 2022 - Elsevier
Epidemiological evidence shows that diabetic patients have an increased cancer risk and a
higher mortality rate. Glucose could play a central role in metabolism and growth of many …

Does DPP-IV inhibition offer new avenues for therapeutic intervention in malignant disease?

P Busek, JS Duke-Cohan, A Sedo - Cancers, 2022 - mdpi.com
Simple Summary There is growing interest in identifying the effects of antidiabetic agents on
cancer risk, progression, and anti-cancer treatment due to the long-term use of these …

Cancer biology and prevention in diabetes

SP Srivastava, JE Goodwin - Cells, 2020 - mdpi.com
The available evidence suggests a complex relationship between diabetes and cancer.
Epidemiological data suggest a positive correlation, however, in certain types of cancer, a …

The CXCL12/CXCR4/ACKR3 axis in the tumor microenvironment: signaling, crosstalk, and therapeutic targeting

MJ Smit, G Schlecht-Louf, M Neves… - Annual review of …, 2021 - annualreviews.org
Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate
ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment …

Biomimetic nanomedicine coupled with neoadjuvant chemotherapy to suppress breast cancer metastasis via tumor microenvironment remodeling

H Liu, J Wang, M Wang, Y Wang, S Shi… - Advanced Functional …, 2021 - Wiley Online Library
The biomimetic enzyme activity of cerium oxide nanoparticles (CeNPs) prefers ultrasmall
particle size and bare surface. Unfortunately, those two features are not favorable for its in …