Structural simplification of natural products

S Wang, G Dong, C Sheng - Chemical Reviews, 2019 - ACS Publications
Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions

MG Vinogradov, OV Turova, SG Zlotin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …

Structure-function of neuronal nicotinic acetylcholine receptor inhibitors derived from natural toxins

TNT Ho, N Abraham, RJ Lewis - Frontiers in Neuroscience, 2020 - frontiersin.org
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-
gated ion channels that mediate fast neurotransmission in the central and peripheral …

Additional acetylcholine (ACh) binding site at α4/α4 interface of (α4β2) 2α4 nicotinic receptor influences agonist sensitivity

S Mazzaferro, N Benallegue, A Carbone… - Journal of Biological …, 2011 - ASBMB
Nicotinic acetylcholine receptor (nAChR) α4 and β2 subunits assemble in two alternate
stoichiometries to produce (α4β2) 2 α4 and (α4β2) 2 β2, which display different agonist …

[图书][B] Progress in the chemistry of organic natural products

AD Kinghorn, H Falk, S Gibbons, Y Asakawa, JK Liu… - 2021 - Springer
Termites (Isoptera), which are a suborder of the cockroaches, are the oldest eusocial insects
[1–3]. It is assumed that they diverged from the Cryptocercoidae, woodfeeding cockroaches …

[HTML][HTML] Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity

AR Silva, C Grosso, C Delerue-Matos… - European journal of …, 2019 - Elsevier
Given their therapeutic activity, natural products have been used in traditional medicines
throughout the centuries. The growing interest of the scientific community in …

Ligand binding and homology modelling of insect odorant‐binding proteins

H Venthur, A Mutis, JJ Zhou… - Physiological …, 2014 - Wiley Online Library
This review describes the main characteristics of odorant‐binding proteins (OBP s) for
homology modelling and presents a summary of structure prediction studies on insect OBP …

The genus Erythrina L.: A review on its alkaloids, preclinical, and clinical studies

DF Rambo, R Biegelmeyer, NSB Toson… - Phytotherapy …, 2019 - Wiley Online Library
Erythrina L. genus (Fabaceae) comprises about 115 species, and it has been extensively
studied, mainly because of its alkaloids, which have pharmacological properties …

Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists

F Crestey, AA Jensen, M Borch… - Journal of Medicinal …, 2013 - ACS Publications
The synthesis of a new series of Erythrina alkaloid analogues and their pharmacological
characterization at various nicotine acetylcholine receptor (nAChR) subtypes are described …

Leishmanicidal evaluation of tetrahydroprotoberberine and spirocyclic erythrina-alkaloids

DR Callejon, TB Riul, LGP Feitosa, T Guaratini… - Molecules, 2014 - mdpi.com
Leishmaniasis is one of the World's most problematic diseases in developing countries.
Traditional medicines to treat leishmaniasis have serious side effects, as well as significant …