Exposure to per-and polyfluoroalkyl substances and markers of liver injury: a systematic review and meta-analysis

E Costello, S Rock, N Stratakis, SP Eckel… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: Experimental evidence indicates that exposure to certain pollutants is
associated with liver damage. Per-and polyfluoroalkyl substances (PFAS) are persistent …

Per‐and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research

SE Fenton, A Ducatman, A Boobis… - Environmental …, 2021 - Wiley Online Library
Reports of environmental and human health impacts of per‐and polyfluoroalkyl substances
(PFAS) have greatly increased in the peer‐reviewed literature. The goals of the present …

Early life exposure to per-and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of …

BE Blake, SE Fenton - Toxicology, 2020 - Elsevier
Per-and polyfluoroalkyl substances (PFAS) are ubiquitous drinking water contaminants of
concern due to mounting evidence implicating adverse health outcomes associated with …

[HTML][HTML] Exposure to a mixture of legacy, alternative, and replacement per-and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol …

K Roth, Z Yang, M Agarwal, W Liu, Z Peng… - Environment …, 2021 - Elsevier
Background Epidemiological studies have shown Per-and polyfluoroalkyl substances
(PFAS) to be associated with diseases of dysregulated lipid and sterol homeostasis such as …

Risk to human health related to the presence of perfluoroalkyl substances in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific evaluation on the risks to
human health related to the presence of perfluoroalkyl substances (PFAS s) in food. Based …

Mitochondrial determinants of doxorubicin-induced cardiomyopathy

KB Wallace, VA Sardão, PJ Oliveira - Circulation research, 2020 - Am Heart Assoc
Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …

[HTML][HTML] Next generation per-and poly-fluoroalkyl substances: status and trends, aquatic toxicity, and risk assessment

H Mahoney, Y Xie, M Brinkmann, JP Giesy - Eco-Environment & Health, 2022 - Elsevier
Widespread application of poly-and per-fluoroalkyl substances (PFAS) has resulted in some
substances being ubiquitous in environmental matrices. That and their resistance to …

[HTML][HTML] Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort

JA Goodrich, D Walker, X Lin, H Wang, T Lim… - JHEP Reports, 2022 - Elsevier
Background & Aims Exposure to poly-and perfluoroalkyl substances (PFAS), a class of
persistent organic pollutants, is ubiquitous. Animal studies suggest that PFAS may increase …

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

S Fragki, H Dirven, T Fletcher… - Critical reviews in …, 2021 - Taylor & Francis
Associations between per-and polyfluoroalkyl substances (PFASs) and increased blood
lipids have been repeatedly observed in humans, but a causal relation has been debated …

[HTML][HTML] Perfluoroalkyl substances and severity of nonalcoholic fatty liver in children: an untargeted metabolomics approach

R Jin, R McConnell, C Catherine, S Xu, DI Walker… - Environment …, 2020 - Elsevier
Background Toxicant-associated steatohepatitis has been described in adults but less is
known regarding the role of toxicants in liver disease of children. Perfluoroalkyl substances …