Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …
Glaucoma: now and beyond
H Jayaram, M Kolko, DS Friedman, G Gazzard - The Lancet, 2023 - thelancet.com
The glaucomas are a group of conditions leading to irreversible sight loss and characterised
by progressive loss of retinal ganglion cells. Although not always elevated, intraocular …
by progressive loss of retinal ganglion cells. Although not always elevated, intraocular …
[HTML][HTML] Linking the amyloid, tau, and mitochondrial hypotheses of Alzheimer's disease and identifying promising drug targets
Z Fišar - Biomolecules, 2022 - mdpi.com
Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …
[HTML][HTML] Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is
characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the …
characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the …
Neurovascular dysfunction in glaucoma
L Alarcon-Martinez, Y Shiga… - Progress in Retinal and …, 2023 - Elsevier
Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …
[HTML][HTML] Periodontal pathogens and their links to neuroinflammation and neurodegeneration
Pathogens that play a role in the development and progression of periodontitis have gained
significant attention due to their implications in the onset of various systemic diseases …
significant attention due to their implications in the onset of various systemic diseases …
Stress induced aging in mouse eye
Aging, a universal process that affects all cells in an organism, is a major risk factor for a
group of neuropathies called glaucoma, where elevated intraocular pressure is one of the …
group of neuropathies called glaucoma, where elevated intraocular pressure is one of the …
Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma
S El Hajji, Y Shiga, N Belforte, YC Solorio, O Tastet… - Science …, 2024 - science.org
Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature
of neurodegenerative diseases. There is a lack of strategies that target dendritic and …
of neurodegenerative diseases. There is a lack of strategies that target dendritic and …