The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

Alcoholism is a major public health problem and resembles, in many ways, other chronic
relapsing medical conditions. At least 2 separate dimensions of its symptomatology offer …

The central CB 1 cannabinoid receptor has recently been implicated in brain reward
function. In the present study we evaluated first the effects of the selective CB 1 receptor …

The present study was designed to explore the relationship between the cannabinoid and
opioid receptors in animal models of opioid-induced reinforcement. The acute administration …

The past decade has seen an expansion of research and knowledge on pharmacotherapy
for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved …

The mechanisms underlying predisposition to alcohol abuse and alcoholism are poorly
understood. In this study, we evaluated the role of cannabinoid (CB1) receptors in (i) …

Prolonged exposure of the brain to ethanol is a prerequisite for developing ethanol
dependence, but the underlying neural adaptations are unknown. Here we demonstrate that …

This review examines the development of cannabinoid CB1 receptor antagonists as a new
class of therapeutic agents for drug addiction. Abused drugs [alcohol, opiates, Δ9 …

Alcoholism (alcohol dependence) is characterized by a compulsion to seek and ingest
alcohol (ethanol), loss of control over intake, and the emergence of a negative emotional …

Over the past fifty years a significant body of evidence has been compiled suggesting an
interaction between the endocannabinoid (EC) system and alcohol dependence. However …