Structural biology and evolution of the TGF-β family
AP Hinck, TD Mueller… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …
[HTML][HTML] Promiscuity and specificity in BMP receptor activation
TD Mueller, J Nickel - FEBS letters, 2012 - Elsevier
Bone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β
and Activins/Inhibins constitute the TGF-β superfamily of ligands. This superfamily is formed …
and Activins/Inhibins constitute the TGF-β superfamily of ligands. This superfamily is formed …
[HTML][HTML] Complexities of TGF-β targeted cancer therapy
EC Connolly, J Freimuth, RJ Akhurst - International journal of …, 2012 - ncbi.nlm.nih.gov
Many advanced tumors produce excessive amounts of Transforming Growth Factor-β (TGF-
β) which, in normal epithelial cells, is a potent growth inhibitor. However, in oncogenically …
β) which, in normal epithelial cells, is a potent growth inhibitor. However, in oncogenically …
A structure‐based benchmark for protein–protein binding affinity
We have assembled a nonredundant set of 144 protein–protein complexes that have high‐
resolution structures available for both the complexes and their unbound components, and …
resolution structures available for both the complexes and their unbound components, and …
[HTML][HTML] Cooperative assembly of TGF-β superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding
Dimeric ligands of the transforming growth factor-β (TGF-β) superfamily signal across cell
membranes in a distinctive manner by assembling heterotetrameric complexes of …
membranes in a distinctive manner by assembling heterotetrameric complexes of …
Structure of the ternary signaling complex of a TGF-β superfamily member
GP Allendorph, WW Vale… - Proceedings of the …, 2006 - National Acad Sciences
The crystal structure of the complete signaling complex formed between bone
morphogenetic protein 2 (BMP-2) and the extracellular domains (ECDs) of its type I receptor …
morphogenetic protein 2 (BMP-2) and the extracellular domains (ECDs) of its type I receptor …
TGF‐β superfamily co‐receptors in cancer
Transforming growth factor‐β (TGF‐β) superfamily signaling via their cognate receptors is
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …
frequently modified by TGF‐β superfamily co‐receptors. Signaling through SMAD‐mediated …
[HTML][HTML] Integrin-mediated TGFβ activation modulates the tumour microenvironment
NF Brown, JF Marshall - Cancers, 2019 - mdpi.com
TGFβ (transforming growth factor-beta) is a pleotropic cytokine with contrasting effects in
cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting …
cancer. In normal tissue and early tumours, TGFβ acts as a tumour suppressor, limiting …
TGFBR3L is an inhibin B co-receptor that regulates female fertility
E Brûlé, Y Wang, Y Li, YF Lin, X Zhou, L Ongaro… - Science …, 2021 - science.org
Follicle-stimulating hormone (FSH), a key regulator of ovarian function, is often used in
infertility treatment. Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope cells …
infertility treatment. Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope cells …
Role of TGF-β in metastatic colon cancer: it is finally time for targeted therapy
M Villalba, SR Evans, F Vidal-Vanaclocha… - Cell and tissue …, 2017 - Springer
Colorectal cancer (CRC) is one of the most frequent tumor types in Western countries.
Approximately 20% of patients show metastasis at the time of diagnosis, with the liver being …
Approximately 20% of patients show metastasis at the time of diagnosis, with the liver being …