GDF‐15 as a target and biomarker for diabetes and cardiovascular diseases: a translational prospective

R Adela, SK Banerjee - Journal of diabetes research, 2015 - Wiley Online Library
Growth differentiation factor‐15 (GDF‐15) is a stress responsive cytokine. It is highly
expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular …

Pathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia

JA Siddiqui, R Pothuraju, P Khan, G Sharma… - Cytokine & growth factor …, 2022 - Elsevier
Growth differentiation factor 15 or macrophage inhibitory cytokine-1 (GDF15/MIC-1) is a
divergent member of the transforming growth factor β superfamily and has a diverse …

GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation

J Xu, TR Kimball, JN Lorenz, DA Brown… - Circulation …, 2006 - Am Heart Assoc
Here we identified growth-differentiation factor 15 (GDF15)(also known as MIC-1), a
secreted member of the transforming growth factor (TGF)-β superfamily, as a novel …

The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

K Unsicker, B Spittau, K Krieglstein - Cytokine & growth factor reviews, 2013 - Elsevier
Abstract GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-β superfamily,
which is widely distributed in mammalian tissues and has been shown to play multiple roles …

Sublethal irradiation of human tumor cells modulates phenotype resulting in enhanced killing by cytotoxic T lymphocytes

CT Garnett, C Palena, M Chakarborty, KY Tsang… - Cancer research, 2004 - AACR
Local radiation of tumor masses is an established modality for the therapy of a range of
human tumors. It has recently been recognized that doses of radiation, lower than or equal …

The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism

SN Breit, H Johnen, AD Cook, VWW Tsai… - Growth …, 2011 - Taylor & Francis
Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease,
inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis …

Concise review: growth differentiation factor 15 in pathology: a clinical role?

J Corre, B Hébraud, P Bourin - Stem cells translational medicine, 2013 - academic.oup.com
Abstract Growth differentiation factor 15 (GDF15) is a divergent member of the transforming
growth factor β family discovered in a broad range of cells, as indicated by the diversity of its …

Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new …

T Kempf, R Horn-Wichmann, G Brabant… - Clinical …, 2007 - academic.oup.com
Abstract Background: Growth-differentiation factor 15 (GDF15) is a member of the
transforming growth factor β (TGF-β) cytokine superfamily. There has been increasing …

Bone marrow mesenchymal stem cells are abnormal in multiple myeloma

J Corre, K Mahtouk, M Attal, M Gadelorge, A Huynh… - Leukemia, 2007 - nature.com
Recent literature suggested that cells of the microenvironment of tumors could be abnormal
as well. To address this hypothesis in multiple myeloma (MM), we studied bone marrow …

Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine‐1 in cancer

M Mimeault, SK Batra - Journal of cellular physiology, 2010 - Wiley Online Library
Multifunctional macrophage inhibitory cytokine‐1, MIC‐1, is a member of the transforming
growth factor‐β (TGF‐β) superfamily that plays key roles in the prenatal development and …