Dysregulation of intracellular calcium homeostasis is a common hallmark of degenerating
neurons, at some point in the cell death cascade. It is also a feature of many neurological …

Oxidative stress, especially peroxynitrite (ONOO−)-mediated oxidative stress, plays a key
role in diabetes. Mitochondria, as the generating source of ONOO−, may also be the major …

Oxidative stress, especially mediated by peroxynitrite (ONOO), plays a key role in diabetes.
Mitochondria, as the generating source of ONOO-, may also be the major damaging target of …

Sildenafil is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction
and pulmonary hypertension. Proconvulsant effect is a serious adverse event associated …

Hypoxic-ischemic encephalopathy in the perinatal period is the single most common
antecedent of acute brain injury in term and near-term infants and remains a significant …

NO‐mediated toxicity contributes to neuronal damage after hypoxia; however, the molecular
mechanisms involved are still a matter of controversy. Since mitochondria play a key role in …

Introduction 3. Nitric oxide production in hippocampus 3.1. Constitutive and inducible nitric
oxide synthases in hippocampus 3.2. Mechanisms involving glutamate receptors 4 …

ambos cambios dependientes de óxido nítrico. En segundo lugar, se ha establecido que el
precondicionamiento con un estímulo hipóxico de baja intensidad, confiere tolerancia …