Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Neuropathic pain is triggered by lesions to the somatosensory nervous system that alter its
structure and function so that pain occurs spontaneously and responses to noxious and …

Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries,
plays an essential role in the induction and maintenance of chronic pain. However, synaptic …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by helping us respond appropriately in a potentially hostile environment …

A remarkable series of findings over the last decade or so has demonstrated a previously
unrecognized role for CNS glia in many aspects of neuronal functioning including pain …

Chronic pain presents a major unmet clinical problem. The development of more effective
treatments is hindered by our limited understanding of the neuronal circuits underlying …

Although both a loss of spinal inhibitory neurotransmission and the involvement of oxidative
stress have been regarded as important mechanisms in the pathogenesis of pain, the …