The innate immune system detects pathogens via germline-encoded receptors that bind to
conserved pathogen ligands called pathogen-associated molecular patterns (PAMPs). Here …

Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed
predominantly in the skin, mucosa and immune sentinel cells, are key executioners of …

Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell
membrane during the cell death program pyroptosis. GSDMs are activated by proteolytic …

Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore
important to understand why and how the immune system responds to allergens. Here we …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …

The innate immune system uses a distinct set of germline-encoded pattern recognition
receptors (PRRs) to initiate downstream inflammatory cascades. This recognition system is …

Endotoxins and exotoxins are among the most potent bacterial inducers of cytokines. During
infectious processes, the production of inflammatory cytokines including tumor necrosis …

It is becoming increasingly clear that neuroinflammation has a causal role in the
pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic …

Inhibiting the NLRP3 inflammasome mediates inflammation in an extensive number of
preclinical models. As excitement in this field has grown, several companies have recently …