Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …

Cardiovascular disease (CVD) is the leading single cause of morbidity and mortality,
causing over 17. 9 million deaths worldwide per year with associated costs of over $800 …

Myocardial fibrosis (MF) represents the underlying pathologic condition of many cardiac
disease, leading to cardiac dysfunction and heart failure (HF). Biopsy studies have shown …

The immune and fibrotic responses have evolved to work in tandem to respond to pathogen
clearance and promote tissue repair. However, excessive immune and fibrotic responses …

Fibroblasts are the primary regulator of cardiac extracellular matrix (ECM). In response to
disease stimuli cardiac fibroblasts undergo cell state transitions to a myofibroblast …

Myocardial fibrosis is recognized as a key pathological process in the development of
cardiac disease and a target for future therapeutics. Despite this recognition, the assessment …

Fibrosis is a significant global health problem associated with many inflammatory and
degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis …

Myocardial fibrosis and calcification associate with adverse outcomes in nonischemic heart
failure. Cardiac fibroblasts (CF) transition into myofibroblasts (MF) and osteogenic …

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