T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
Roles of IFN-γ in tumor progression and regression: a review
D Jorgovanovic, M Song, L Wang, Y Zhang - Biomarker research, 2020 - Springer
Background Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
MW Rudloff, P Zumbo, NR Favret, JJ Roetman… - Nature …, 2023 - nature.com
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi… - Immunity, 2020 - cell.com
CD8+ T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite
this, the developmental biology of exhausted CD8+ T cells (Tex) remains poorly defined …
this, the developmental biology of exhausted CD8+ T cells (Tex) remains poorly defined …
'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses
D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
K Chamoto, T Yaguchi, M Tajima, T Honjo - Nature Reviews …, 2023 - nature.com
PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
death in T cells. Over the past 30 years, it was found that PD1 has a critical role in avoiding …
Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection
Immunological memory is a hallmark of adaptive immunity and facilitates an accelerated and
enhanced immune response upon re-infection with the same pathogen,. Since the outbreak …
enhanced immune response upon re-infection with the same pathogen,. Since the outbreak …
The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer
CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover,
their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining …
their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining …
Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy
Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …