Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the
mucosal surfaces of the host nasopharynx and upper airway. Through a combination of …

Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory,
gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a …

Sideromycins are antibiotics covalently linked to siderophores. They are actively transported
into gram-positive and gram-negative bacteria. Energy-coupled transport across the outer …

Members of the ABC (for ATP binding cassette) superfamily of integral membrane
transporters function in cellular detoxification, cell-to-cell signaling, and channel regulation …

The acute-phase response is triggered by the presence of infectious agents and danger
signals which indicate hazards for the integrity of the mammalian body. One central feature …

ESX-3 is one of the five type VII secretion systems encoded by the Mycobacterium
tuberculosis genome. We recently showed the essentiality of ESX-3 for M. tuberculosis …

Iron is essential for many biological processes, however, too much or too little iron can result
in a wide variety of pathological consequences, depending on the organ system, tissue or …

Streptococcus pneumoniae is a causative agent for community acquired pneumonia,
bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant …

Human zinc deficiency increases susceptibility to bacterial infection. Although zinc
supplementation therapies can reduce the impact of disease, the molecular basis for …