The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence

GS Zuccoli, VM Saia-Cereda, JM Nascimento… - Frontiers in …, 2017 - frontiersin.org
Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …

Current clinical applications of ω‐6 and ω‐3 fatty acids

S Lee, KM Gura, S Kim, DA Arsenault… - Nutrition in clinical …, 2006 - Wiley Online Library
Background: Recent years have brought a resurgence of research interest in fatty acids, with
studied fields running the gamut of human disease. This movement has run in parallel with …

Potential metabolite markers of schizophrenia

J Yang, T Chen, L Sun, Z Zhao, X Qi, K Zhou… - Molecular …, 2013 - nature.com
Schizophrenia is a severe mental disorder that affects 0.5–1% of the population worldwide.
Current diagnostic methods are based on psychiatric interviews, which are subjective in …

Mapping the serum proteome to neurological diseases using whole genome sequencing

G Png, A Barysenka, L Repetto, P Navarro… - Nature …, 2021 - nature.com
Despite the increasing global burden of neurological disorders, there is a lack of effective
diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have …

Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia

JF Wang, L Shao, X Sun, LT Young - Bipolar disorders, 2009 - Wiley Online Library
Background: Recent studies indicate the presence of mitochondrial dysfunction in brains of
subjects with bipolar disorder (BD). Because the mitochondrial electron transport chain is a …

Reduced erythrocyte membrane polyunsaturated fatty acid levels indicate diminished treatment response in patients with multi-versus first-episode schizophrenia

N Li, P Yang, M Tang, Y Liu, W Guo, B Lang, J Wang… - Schizophrenia, 2022 - nature.com
Antipsychotic effects seem to decrease in relapsed schizophrenia patients and the
underlying mechanisms remain to be elucidated. Based on the essential role of …

Altered thalamic membrane phospholipids in schizophrenia: a postmortem study

A Schmitt, K Wilczek, K Blennow, A Maras, A Jatzko… - Biological …, 2004 - Elsevier
BACKGROUND: Membrane lipids are important mediators of neuronal function. In a
postmortem study, we measured membrane lipid components in the left thalamus of …

Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms

MC Hsu, YS Huang, WC Ouyang - Lipids in health and disease, 2020 - Springer
Background Schizophrenia is a serious long-term psychotic disorder marked by positive and
negative symptoms, severe behavioral problems and cognitive function deficits. The cause …

Fungal hallucinogens psilocin, ibotenic acid, and muscimol: analytical methods and biologic activities

K Stebelska - Therapeutic Drug Monitoring, 2013 - journals.lww.com
Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have
been proposed for recreational use and popularized since the 1960s, XX century. Despite …

Omega-3 fatty acid supplementation changes intracellular phospholipase A2 activity and membrane fatty acid profiles in individuals at ultra-high risk for psychosis

S Smesny, B Milleit, UC Hipler, C Milleit… - Molecular …, 2014 - nature.com
The identification of an ultra-high risk (UHR) profile for psychosis and a greater
understanding of its prodrome have led to increasing interest in early intervention to delay or …