The field of immuno-oncology has revolutionized cancer patient care and improved survival
and quality of life for patients. Much of the focus in the field has been on exploiting the power …

Background: Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all kidney cancers
and has a poor prognosis. Recent studies have shown that copper-dependent, regulated …

Lung cancer is the leading cause of cancer-related death worldwide. Although natural killer
(NK) cells are garnering interest as a potential anticancer therapy because they selectively …

Hypoxia is a common feature of solid tumours affecting their biology and response to
therapy. One of the main transcription factors activated by hypoxia is hypoxia-inducible …

When we can understand what natural killer (NK) cells recognize during an encounter with
an infectious pathogen or a tumor cell, and when we can understand how the NK cell …

The tumor immune microenvironment (TIME) has largely been reported to cooperate on
tumor onset and progression, as a consequence of the phenotype/functional plasticity and …

Severe heterogeneity within glioblastoma has spurred the notion that disrupting the interplay
between multiple elements on immunosuppression is at the core of meaningful anti-tumor …

The inflammasomes play crucial roles in inflammation and cancer development, while the
PD-1/PD-L1 pathway is critical for immune suppression in the tumor microenvironment …

The fruitful results of tumor immunotherapy establish its indispensable status in the
regulation of the tumorous immune context. It seems that the treatment of programmed cell …

Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However,
NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets …