Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

Premature ovarian insufficiency (POI) is a major cause of female infertility due to early loss of
ovarian function. POI is a heterogeneous condition, and its molecular etiology is unclear. To …

PURPOSE Total body irradiation (TBI) before allogeneic hematopoietic stem cell
transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …

A now frequently used method to edit mammalian genomes uses the nucleases
CRISPR/Cas9 and CRISPR/Cpf1 or the nickase CRISPR/Cas9n to introduce double-strand …

Purpose: The purpose of this study is to characterize the mutational landscape across the
spectrum of urothelial carcinoma (UC) to identify mutational features and potential …

Differences in DNA repair capacity have been hypothesized to underlie the great range of
maximum lifespans among mammals. However, measurements of individual DNA repair …

Background In metastatic urothelial carcinoma (mUC), predictive biomarkers that correlate
with response to immune checkpoint inhibitors (ICIs) are lacking. Here, we interrogated …

Covalent DNA modifications, such as 5-methylcytosine (5mC), are increasingly the focus of
numerous research programs. In eukaryotes, both 5mC and 5-hydroxymethylcytosine …