HIRA-dependent provision of histone H3. 3 in active chromatin ensures genome compartmentalisation
T Karagyozova, A Gatto, A Forest, JP Quivy… - bioRxiv, 2024 - biorxiv.org
The mammalian genome, organised into chromatin, adopts a three-dimensional (3D) folding
within the cell nucleus with spatially segregated active and repressed compartments, termed …
within the cell nucleus with spatially segregated active and repressed compartments, termed …
HIRA defines early replication initiation zones independently of their genome compartment
T Karagyozova, A Gatto, A Forest, JP Quivy… - bioRxiv, 2024 - biorxiv.org
Chromatin states and 3D architecture have been used as proxy to identify replication
initiation zones (IZs) in mammalian cells. While they do often correlate, their functional …
initiation zones (IZs) in mammalian cells. While they do often correlate, their functional …
Polymer Model Integrates Super-Resolution Imaging and Epigenomic Sequencing to Elucidate the Role of Epigenetic Reactions in Shaping 4D Chromatin …
Chromatin, with its complex spatial and temporal organization, plays a crucial role in
regulating gene expression. Recent advancements in super-resolution microscopy have …
regulating gene expression. Recent advancements in super-resolution microscopy have …
Rearrangement of 3D genome organization in breast cancer epithelial-mesenchymal transition and metastasis organotropism
Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to
certain organs such as bone, lung, liver, and brain. One potential explanation for this …
certain organs such as bone, lung, liver, and brain. One potential explanation for this …
Deciphering Pre-existing and Induced 3D Genome Architecture Changes involved in Constricted Melanoma Migration
C Playter, R Golloshi, JH Garretson, AR Gonzalez… - bioRxiv, 2024 - biorxiv.org
Metastatic cancer cells traverse constricted spaces that exert forces on their nucleus and the
genomic contents within. Cancerous tumors are highly heterogeneous and not all cells …
genomic contents within. Cancerous tumors are highly heterogeneous and not all cells …