Systems biology of metabolism
J Nielsen - Annual review of biochemistry, 2017 - annualreviews.org
Metabolism is highly complex and involves thousands of different connected reactions; it is
therefore necessary to use mathematical models for holistic studies. The use of …
therefore necessary to use mathematical models for holistic studies. The use of …
Mitigating release of the potent greenhouse gas N2O from the nitrogen cycle–could enzymic regulation hold the key?
D Richardson, H Felgate, N Watmough… - Trends in …, 2009 - cell.com
When faced with a shortage of oxygen, many bacterial species use nitrate to support
respiration via the process of denitrification. This takes place extensively in nitrogen-rich …
respiration via the process of denitrification. This takes place extensively in nitrogen-rich …
[图书][B] An introduction to systems biology: design principles of biological circuits
U Alon - 2019 - api.taylorfrancis.com
Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …
engineering approach to systems biology. Alon provides nicely written appendices to …
Network-based prediction of human tissue-specific metabolism
Direct in vivo investigation of mammalian metabolism is complicated by the distinct
metabolic functions of different tissues. We present a computational method that successfully …
metabolic functions of different tissues. We present a computational method that successfully …
Metabolic networks in motion: 13C‐based flux analysis
U Sauer - Molecular systems biology, 2006 - embopress.org
Many properties of complex networks cannot be understood from monitoring the
components—not even when comprehensively monitoring all protein or metabolite …
components—not even when comprehensively monitoring all protein or metabolite …
The nature of systems biology
FJ Bruggeman, HV Westerhoff - TRENDS in Microbiology, 2007 - cell.com
The advent of functional genomics has enabled the molecular biosciences to come a long
way towards characterizing the molecular constituents of life. Yet, the challenge for biology …
way towards characterizing the molecular constituents of life. Yet, the challenge for biology …
How fast‐growing bacteria robustly tune their ribosome concentration to approximate growth‐rate maximization
Maximization of growth rate is an important fitness strategy for bacteria. Bacteria can achieve
this by expressing proteins at optimal concentrations, such that resources are not wasted …
this by expressing proteins at optimal concentrations, such that resources are not wasted …
iMAT: an integrative metabolic analysis tool
iMAT is an Integrative Metabolic Analysis Tool, enabling the integration of transcriptomic and
proteomic data with genome-scale metabolic network models to predict enzymes' metabolic …
proteomic data with genome-scale metabolic network models to predict enzymes' metabolic …
Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism
JM Buescher, W Liebermeister, M Jules, M Uhr… - Science, 2012 - science.org
Adaptation of cells to environmental changes requires dynamic interactions between
metabolic and regulatory networks, but studies typically address only one or a few layers of …
metabolic and regulatory networks, but studies typically address only one or a few layers of …
Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model
Motivation: The availability of modern sequencing techniques has led to a rapid increase in
the amount of reconstructed metabolic networks. Using these models as a platform for the …
the amount of reconstructed metabolic networks. Using these models as a platform for the …