In biology, it can be argued that if the genome contains the script for a cell's life cycle, then
the proteome constitutes an ensemble cast of actors that brings these instructions to life …

Native mass spectrometry (nMS) is evolving into a workhorse for structural biology. The
plethora of online and offline preparation, separation, and purification methods as well as …

Mass spectrometry (MS) has become a crucial technique for the analysis of protein
complexes. Native MS has traditionally examined protein subunit arrangements, while …

The analysis of peptides and proteins as well as the grander scope of proteomics (large
scale study of proteins) has been advanced by the development of a versatile array of ion …

Protein complexes exhibit great diversity in protein membership, post-translational
modifications and noncovalent cofactors, enabling them to function as the actuators of many …

Native mass spectrometry (MS) of proteins and protein assemblies reveals size and binding
stoichiometry, but elucidating structures to understand their function is more challenging …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

The structural diversity of natural products offers unique opportunities for drug discovery, but
challenges associated with their isolation and screening can hinder the identification of drug …

METHODS Herein we describe alternative dissociation methods commonly employed within
mass spectrometry with an emphasis on the outcomes of probing native protein complexes …

Mass spectrometry (MS) is a powerful tool for determining the mass of biomolecules with
high accuracy and sensitivity. MS performed under so‐called “native conditions”(native MS) …