A review: Structure-activity relationship and antibacterial activities of Quinoline based hybrids
The drug resistance problem is most acute in the case of bacteria. There is always a need to
develop novel antibacterial drugs with better mechanisms of action. Most of the quinoline …
develop novel antibacterial drugs with better mechanisms of action. Most of the quinoline …
Recent update on antibacterial and antifungal activity of quinoline scaffolds
A Dorababu - Archiv der Pharmazie, 2021 - Wiley Online Library
Although most of the heterocycles have been reported to possess a significant
pharmacological activity, only a few of them, namely quinoline derivatives, have exhibited …
pharmacological activity, only a few of them, namely quinoline derivatives, have exhibited …
Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies
SI Eissa, AM Farrag, SY Abbas, MF El Shehry… - Bioorganic …, 2021 - Elsevier
One of the best ways to design new biocidal agents is synthesizing hybrid molecules by
combining two or more bioactive moieties in a single molecular scaffold. So, new series of …
combining two or more bioactive moieties in a single molecular scaffold. So, new series of …
Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking
Based on the biologically active heterocycle quinoline, a series (18a-p) of quinoline
hydrazone analogues were prepared, starting from 6-bromo/6-chloro-2-methyl-quinolin-4-yl …
hydrazone analogues were prepared, starting from 6-bromo/6-chloro-2-methyl-quinolin-4-yl …
Novel polyhydroquinoline-hydrazide-linked Schiff's base derivatives: multistep synthesis, antimicrobial, and calcium-channel-blocking activities
Polyhydroquinoline (PHQ) are the unsymmetrical Hantzsch derivatives of 1, 4-
dihydropyridines with several biological applications. In this work, twenty-five (3–27) new …
dihydropyridines with several biological applications. In this work, twenty-five (3–27) new …
An updated review on the synthesis and antibacterial activity of molecular hybrids and conjugates bearing imidazole moiety
R Rossi, M Ciofalo - Molecules, 2020 - mdpi.com
The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the
nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists …
nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists …
Novel polyhydroquinoline Schiff's base derivatives: synthesis, characterization, in vitro α-glucosidase inhibitory, and molecular docking studies
N Shahab, D Kong, M Ali, A Alam, N Ur Rehman… - Research on Chemical …, 2023 - Springer
Novel Schiff's base hydrazone derivatives (1–24) based on polyhydroquinoline (PHQ) were
synthesized in good to excellent yields via three step reactions. Compound 1 (starting …
synthesized in good to excellent yields via three step reactions. Compound 1 (starting …
Ultrasonic energy for construction of bioactive heterocycles
The ultrasonic energy has been revisited and applied for the synthesis of bioactive
molecules in a short time and green method. These compounds can exhibit anticancer …
molecules in a short time and green method. These compounds can exhibit anticancer …
Current pharmaceutical aspects of synthetic quinoline derivatives
Quinoline derivatives are considered broad-spectrum pharmacological compounds that
exhibit a wide range of biological activities. Integration of quinoline moiety can improve its …
exhibit a wide range of biological activities. Integration of quinoline moiety can improve its …
Cytotoxicity of 4-substituted quinoline derivatives: anticancer and antileishmanial potential
CA Costa, RM Lopes, LS Ferraz, GNN Esteves… - Bioorganic & Medicinal …, 2020 - Elsevier
Chemical modifications of quinoline moiety have been recognized as a useful strategy to
development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted …
development of new drugs. Here, the cytotoxicity of a set of twenty-four 4-substituted …