Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

The microenvironment encompasses all components of a tumor other than the cancer cells
themselves. It is highly heterogenous, comprising a cellular component that includes …

Helminth parasitic infections are a major global health and social burden. The host defence
against helminths such as Nippostrongylus brasiliensis is orchestrated by type 2 cell …

Background & Aims Countries endemic for parasitic infestations have a lower incidence of
Crohn's disease (CD) than nonendemic countries, and there have been anecdotal reports of …

Small populations of adult stem cells are responsible for the remarkable ability of the
epithelial lining of the intestine to be efficiently renewed and repaired throughout life. The …

To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale
analysis of 276 samples, analysing exome sequence, DNA copy number, promoter …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

Generating a precise cellular and molecular cartography of the human embryo is essential
to our understanding of the mechanisms of organogenesis in normal and pathological …