Neuropathic pain in humans arises as a consequence of injury or disease of somatosensory
nervous system at peripheral or central level. Peripheral neuropathic pain is more common …

Abstract Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …

Chronic visceral pain is a major challenge for both patients and health providers. Although
the central sensitization of the brain is thought to play an important role in the development …

The spinal N-methyl-d-aspartate receptor (NMDAR), particularly their subtypes NR2A and
NR2B, plays pivotal roles in neuropathic and inflammatory pain. However, the roles of NR2A …

Abstract Background Complex Regional Pain Syndrome (CRPS) leads to a debilitating
chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely …

Chronic pain is a common, complex and unpleasant sensation following nerve injury, tissue
trauma, inflammatory diseases, infection and cancer. It affects up to 25% of adults and is …

Abstract Alcohol Use Disorder (AUD) is a chronic relapsing disorder characterized by
compulsive alcohol intake, loss of control over alcohol intake, and a negative emotional …

Keratinocytes are the predominant block-building cells in the epidermis. Emerging evidence
has elucidated the roles of keratinocytes in a wide range of pathophysiological processes …

Kinesins (KIF's) are the motor proteins which are recently reported to be involved in the
trafficking of nociceptors leading to chronic pain. Aurora kinases are known to be involved in …

Bone fracture following traumatic injury or due to osteoporosis is characterized by severe
pain and motor impairment and is a major cause of global mortality and disability. Fracture …