Peripheral mechanisms of neuropathic pain—the role of neuronal and non-neuronal interactions and their implications for topical treatment of neuropathic pain
M Kocot-Kępska, R Zajączkowska, J Mika… - Pharmaceuticals, 2021 - mdpi.com
Neuropathic pain in humans arises as a consequence of injury or disease of somatosensory
nervous system at peripheral or central level. Peripheral neuropathic pain is more common …
nervous system at peripheral or central level. Peripheral neuropathic pain is more common …
The role of neuroinflammation in complex regional pain syndrome: a comprehensive review
Abstract Complex Regional Pain Syndrome (CRPS) is an excess and/or prolonged pain and
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …
inflammation condition that follows an injury to a limb. The pathogenesis of CRPS is …
Identification of a glutamatergic claustrum-anterior cingulate cortex circuit for visceral pain processing
QY Xu, HL Zhang, H Du, YC Li, FH Ji, R Li… - Journal of …, 2022 - Soc Neuroscience
Chronic visceral pain is a major challenge for both patients and health providers. Although
the central sensitization of the brain is thought to play an important role in the development …
the central sensitization of the brain is thought to play an important role in the development …
Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain
YY Zhang, F Liu, ZH Fang, YL Li, HL Liao… - Brain, behavior, and …, 2022 - Elsevier
The spinal N-methyl-d-aspartate receptor (NMDAR), particularly their subtypes NR2A and
NR2B, plays pivotal roles in neuropathic and inflammatory pain. However, the roles of NR2A …
NR2B, plays pivotal roles in neuropathic and inflammatory pain. However, the roles of NR2A …
Animal models of complex regional pain syndrome: a scoping review
J Palandi, JM Mack, IL De Araújo, M Farina… - Neuroscience & …, 2023 - Elsevier
Abstract Background Complex Regional Pain Syndrome (CRPS) leads to a debilitating
chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely …
chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely …
The involvement of caspases in neuroinflammation and neuronal apoptosis in chronic pain and potential therapeutic targets
H Zhang, N Li, Z Li, Y Li, Y Yu, L Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
Chronic pain is a common, complex and unpleasant sensation following nerve injury, tissue
trauma, inflammatory diseases, infection and cancer. It affects up to 25% of adults and is …
trauma, inflammatory diseases, infection and cancer. It affects up to 25% of adults and is …
The Sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice
SG Quadir, SM Tanino, CD Rohl, JJ Sahn, EJ Yao… - …, 2021 - Elsevier
Abstract Alcohol Use Disorder (AUD) is a chronic relapsing disorder characterized by
compulsive alcohol intake, loss of control over alcohol intake, and a negative emotional …
compulsive alcohol intake, loss of control over alcohol intake, and a negative emotional …
Emerging roles of keratinocytes in nociceptive transduction and regulation
X Xu, C Yu, L Xu, J Xu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Keratinocytes are the predominant block-building cells in the epidermis. Emerging evidence
has elucidated the roles of keratinocytes in a wide range of pathophysiological processes …
has elucidated the roles of keratinocytes in a wide range of pathophysiological processes …
Inhibition of pan-Aurora kinase attenuates evoked and ongoing pain in nerve injured rats via regulating KIF17-NR2B mediated signaling
Kinesins (KIF's) are the motor proteins which are recently reported to be involved in the
trafficking of nociceptors leading to chronic pain. Aurora kinases are known to be involved in …
trafficking of nociceptors leading to chronic pain. Aurora kinases are known to be involved in …
Chronic pain after bone fracture: Current insights into molecular mechanisms and therapeutic strategies
Y Zhao, H Zhang, N Li, J Li, L Zhang - Brain Sciences, 2022 - mdpi.com
Bone fracture following traumatic injury or due to osteoporosis is characterized by severe
pain and motor impairment and is a major cause of global mortality and disability. Fracture …
pain and motor impairment and is a major cause of global mortality and disability. Fracture …