Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

This review covers the pathogenesis of ischemic stroke and future directions regarding
therapeutic options after injury. Ischemic stroke is a devastating disease process affecting …

While the mainstay of acute stroke treatment includes revascularization via recombinant
tissue plasminogen activator or mechanical thrombectomy, only a minority of stroke patients …

Abstract Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell
differentiation factor, capable of inducing the maturation of B cells into antibody-producing …

Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …

Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

The use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic
strategy for CNS-related conditions. Research in the last decade strongly suggests that MSC …

Recent studies have revealed that the adult mammalian brain has the capacity to regenerate
some neurons after various insults. However, the precise mechanism of insult-induced …