Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are
public health problems and represent major therapeutic challenges. Non-steroidal anti …

Ferroptosis is an iron-and reactive oxygen species (ROS)-dependent form of regulated cell
death, that has been implicated in Alzheimer's disease and Parkinson's disease. Inhibition of …

Alzheimer's disease (AD), the most common form of dementia, currently affects 40–50
million people worldwide. Despite the extensive research into amyloid β (Aβ) deposition and …

The homologous cytokines macrophage migration inhibitory factor (MIF) and d-dopachrome
tautomerase (d-DT or MIF2) play key roles in cancers. Molecules binding to the MIF …

A copper-catalyzed protocol for the construction of various 2-aryl (alkyl)-3-acylquinolines or
3-arylquinolines using readily available anthranils and 1, 3-diketones or aldehydes as …

Lung cancer is the leading global cause of cancer‐related deaths. Although smoking
cessation is the best prevention, 50% of lung cancer diagnoses occur in people who have …

Lipoxygenases (LOXs) catalyze the (per) oxidation of fatty acids that serve as important
mediators for cell signaling and inflammation. These reactions are initiated by a CH …

Abstract A series of thieno [2, 3-d] pyrimidine alkyne Mannich base derivatives (7a-e, 8a-e)
and thieno [2, 3-d] pyrimidine 1, 3, 4-oxadiazole derivatives (9a-e, 10a-e) have been …

A novel series of 2‐cyano‐N‐(tetrahydrobenzo [b] thiophen‐2‐yl) acrylamide derivatives
were synthesized and their structures were confirmed using several spectral tools. All …