Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

MicroRNAs (miRNAs) are small non-coding RNAs with the capability of modulating gene
expression at the post-transcriptional level either by inhibiting messenger RNA (mRNA) …

Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …

Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …