Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth

Y Shao, SC Forster, E Tsaliki, K Vervier, A Strang… - Nature, 2019 - nature.com
Immediately after birth, newborn babies experience rapid colonization by microorganisms
from their mothers and the surrounding environment. Diseases in childhood and later in life …

Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen

CL Gorrie, M Mirčeta, RR Wick, LM Judd… - Nature …, 2022 - nature.com
Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

AC Dowell, MS Butler, E Jinks, G Tut, T Lancaster… - Nature …, 2022 - nature.com
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for
this outcome is unclear. Here we compare antibody and cellular immunity in children (aged …

Prevalence of colistin resistance of Klebsiella pneumoniae isolates in Iran: a systematic review and meta-analysis

N Narimisa, F Goodarzi, S Bavari - Annals of clinical microbiology and …, 2022 - Springer
Objective Klebsiella pneumoniae is a gram-negative pathogen common cause of
nosocomial infections. Colistin is a last resort antibiotic to treat infections caused by K …

Distinct evolutionary dynamics of horizontal gene transfer in drug resistant and virulent clones of Klebsiella pneumoniae

KL Wyres, RR Wick, LM Judd, R Froumine… - PLoS …, 2019 - journals.plos.org
Klebsiella pneumoniae has emerged as an important cause of two distinct public health
threats: multi-drug resistant (MDR) healthcare-associated infections and drug susceptible …

[HTML][HTML] Novel subclone of carbapenem-resistant Klebsiella pneumoniae sequence type 11 with enhanced virulence and transmissibility, China

K Zhou, T Xiao, S David, Q Wang, Y Zhou… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
We aimed to clarify the epidemiologic and clinical importance of evolutionary events that
occurred in carbapenem-resistant Klebsiella pneumoniae (CRKP). We collected 203 CRKP …

Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae

M Nguyen, T Brettin, SW Long, JM Musser, RJ Olsen… - Scientific reports, 2018 - nature.com
Antimicrobial resistant infections are a serious public health threat worldwide. Whole
genome sequencing approaches to rapidly identify pathogens and predict antibiotic …

Genomic profiling reveals distinct routes to complement resistance in Klebsiella pneumoniae

FL Short, G Di Sario, NT Reichmann… - Infection and …, 2020 - Am Soc Microbiol
The serum complement system is a first line of defense against bacterial invaders.
Resistance to killing by serum enhances the capacity of Klebsiella pneumoniae to cause …

Molecular Epidemiological Insights into Colistin-Resistant and Carbapenemases-Producing Clinical Klebsiella pneumoniae Isolates

D Di Tella, M Tamburro, G Guerrizio… - Infection and Drug …, 2019 - Taylor & Francis
Purpose Carbapenemases-producing Klebsiella pneumoniae are challenging antimicrobial
therapy of hospitalised patients, which is further complicated by colistin resistance. This …