Cystic fibrosis related diabetes (CFRD) is a distinct form of diabetes that is associated with
significantly increased morbidity and mortality in the CF population. The primary etiology is …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Genetic risk variants that have been identified in genome-wide association studies of
complex diseases are primarily non-coding. Translating these risk variants into mechanistic …

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is
characterized by dysfunction of insulin-producing pancreatic islet β cells 1, 2. T2D genome …

Over the last two decades, improved access to human islets and the development of human
islet distribution networks have enabled the use of millions of human islets in hundreds of …

Background Cystic fibrosis related diabetes (CFRD) is associated with pulmonary decline
and compromised nutritional status. Emerging data suggest that CFTR dysfunction may play …

Cystic Fibrosis (CF) was the most common fatal single-gene disorder in Caucasians.
However, CF is found in non-Caucasians, including people of 100% African descent, and …

Highly effective CFTR modulator drug therapy is increasingly available to those with cystic
fibrosis. Multiple observational research studies are now being conducted to better …

Beta cells of the pancreatic islet express many different types of ion channels. These
channels reside in the β-cell plasma membrane as well as subcellular organelles and their …

Background The effect of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on glucose
tolerance and/or cystic-fibrosis-related diabetes (CFRD) is not well understood. We …