Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Inflammation is currently considered a prime target for the development of new stroke
therapies. In the acute phase of ischemic stroke, microglia are activated and then circulating …

Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Ischemic stroke is the third cause of death in the developed countries and the main reason
of severe disability. Brain ischemia leads to the production of damage-associated molecular …

Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to
brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged …

Recent clinical and experimental studies have highlighted a complex role for the immune
system in the pathophysiological changes that occur after acute stroke. Sensors of the innate …

Background The brain's initial innate response to stroke is primarily mediated by microglia,
the resident macrophage of the CNS. However, as early as 4 h after stroke, the blood–brain …

Infections are a leading cause of morbidity and mortality in patients with acute CNS injury. It
has recently become clear that CNS injury significantly increases susceptibility to infection …

There is an urgent need for improved diagnostics and therapeutics for acute ischemic stroke.
This is the focus of numerous research projects involving in vitro studies, animal models and …

Cerebral palsy is caused by injury or developmental disturbances to the immature brain and
leads to substantial motor, cognitive, and learning deficits. In addition to developmental …