Studies over the past two decades have led to major advances in the pathogenesis of
Paget's disease of bone (PDB) and particularly on the role of genetic factors. Germline …

Paget disease of bone (PDB) is a skeletal disorder common in Western Europe but
extremely rare in the Indian subcontinent and Far East. The condition has a strong genetic …

Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by
increased osteoclast-mediated bone resorption and a subsequent compensatory increase in …

Paget's disease of bone (PDB) has become less common over recent decades but it is
unclear if this has impacted on clinical presentation. Here we evaluated the presenting …

Adult PD of bone is the second commonest metabolic bone condition after osteoporosis. The
condition is characterized by increased bone cell activity, with bone-resorbing osteoclasts …

Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and
leads to changes in the shape and size of affected bones and to skeletal, articular and …

Paget's disease is a chronic focal high turnover bone disorder that is primarily present in
middle-aged or older adults. It seems to be restricted to humans and has no clear parallels …

Paget's disease of the bone is a prevalent bone disease characterized by disorganized
bone remodeling; however, it is comparatively uncommon in East Asian countries, including …

Paget's disease of bone (PDB) is the second most common metabolic bone disorder, after
osteoporosis. It is characterised by focal areas of increased and disorganised bone turnover …

The first clinical use of bisphosphonates was in Paget's disease of bone (PDB) when
disodium etidronate was found to be effective at suppressing metabolic activity of the …