The clinical translation of promising products, technologies and interventions from the
disciplines of nanomedicine and cell therapy has been slow and inefficient. In part …

Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-
posterior body axis establishment and subsequent spinal cord development, but these …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which
affects about 0.3% of the general population. As the population in the developed world ages …

Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

Background and Aims NAFLD is a growing public health burden. However, the
pathogenesis of NAFLD has not yet been fully elucidated, and the importance of genetic …

During the last five years, there has been a significantly increasing interest in adult adipose
stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant …

Despite considerable effort and significant therapeutic advances, age-related macular
degeneration (AMD) remains the commonest cause of blindness in the developed world …