The potential of modified and multimeric antimicrobial peptide materials as superbug killers

T Matthyssen, W Li, JA Holden, JC Lenzo… - Frontiers in …, 2022 - frontiersin.org
Antimicrobial peptides (AMPs) are found in nearly all living organisms, show broad spectrum
antibacterial activity, and can modulate the immune system. Furthermore, they have a very …

Efficacy and toxicity studies of novel α-MSH analogues with antibiofilm action and β-lactam resensitization potential against MRSA

S Mumtaz, S Behera, S Joshi… - ACS Infectious …, 2022 - ACS Publications
Methicillin-resistant Staphylococcus aureus (MRSA), a biofilm-forming recalcitrant pathogen
with a multidrug-resistant profile, poses a pandemic threat to human health and is the …

Lipidated short analogue of α-Melanocyte stimulating hormone exerts bactericidal activity against the stationary phase of methicillin-resistant staphylococcus aureus …

S Mumtaz, S Behera, K Mukhopadhyay - ACS omega, 2020 - ACS Publications
Stationary phase Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA),
has been widely associated with many persistent infections as well as biofilm-associated …

PL‐101‐WK, a novel tryptophan‐ and lysine‐rich peptide with antimicrobial activity against Staphylococcus aureus

PZ Shahraki, P Farrokh - Peptide Science, 2023 - Wiley Online Library
Designing short antimicrobial peptides (AMPs), which are active against drug‐resistant
bacteria, is a promising way to find new therapeutic agents. In this research, a novel short …

Synergistic Potential of α-Melanocyte Stimulating Hormone Based Analogues with Conventional Antibiotic against Planktonic, Biofilm-Embedded, and Systemic …

S Behera, S Mumtaz, M Singh… - ACS Infectious …, 2023 - ACS Publications
The repotentiation of the existing antibiotics by exploiting the combinatorial potential of
antimicrobial peptides (AMPs) with them is a promising approach to address the challenges …

Proteomic profiling of the endogenous peptides of MRSA and MSSA

H Tu, F Xu, Y Cheng, Q Pan, X Cai, S Wang, S Ge… - PeerJ, 2021 - peerj.com
Staphylococcus aureus is a Gram-positive bacterium that can cause diverse skin and soft
tissue infections. Methicillin-resistant Staphylococcus aureus (MRSA) can cause more …

Mitigating the toxicity of palmitoylated analogue of α-melanocyte stimulating hormone (11–13) by conjugation with gold nanoparticle: characterisation and antibacterial …

S Mitra, AH Mondal, K Mukhopadhyay - World Journal of Microbiology and …, 2022 - Springer
In an attempt to develop potent and non-toxic antimicrobial agent, the palmitoylated
analogue of α-melanocyte stimulating hormone (11–13), Pal-α-MSH (11–13) was …

Interaction with lipopolysaccharide is key to efficacy of tryptophan-and arginine-rich α-melanocyte-stimulating hormone analogs against Gram-negative bacteria

K Tiwari, P Patel, AH Mondal… - Future …, 2024 - Taylor & Francis
Aim: In order to search for novel antibacterial therapeutics against Gram-negative bacteria,
the antibacterial efficacies and mechanism of action of tryptophan-and arginine-rich α …

Investigation of the role of aromatic residues in the antimicrobial peptide BuCATHL4B

MR Necelis, LE Santiago-Ortiz… - Protein and peptide …, 2021 - ingentaconnect.com
Background: Antimicrobial Peptides (AMPs) are an attractive alternative to traditional small
molecule antibiotics as AMPs typically target the bacterial cell membrane. A Trp-rich peptide …

Association of a single amino acid replacement with dorsal pigmentation in a lizard from the Qinghai-Tibetan Plateau

H Tong, G Shao, L Wang, J Li, T Wang, L Zhang… - International Journal of …, 2023 - Elsevier
Reptiles can evolve adaptive colors in different environments, but relatively little is known
about the genetic mechanisms. Here, we identified the MC1R gene and its association with …