We aimed to perform a systematic review and meta-analysis of studies examining the levels
of chemokines in peripheral blood of patients with bipolar disorder (BD) and healthy …

Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …

Background: Bipolar disorder may undertake a progressive course in a subset of patients,
and research efforts have been made to understand the biological basis underlying this …

The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-
lymphocyte ratio (PLR) and systemic immune-inflammatory (SII) index, which provide a …

Excessive alcohol consumption impairs the immune system, induces oxidative stress, and
triggers the activation of peripheral blood (PB) monocytes, thereby contributing to alcoholic …

Disturbances of the immune system and immune responses after activation are a common
finding in neuropsychiatric disorders. Psychotic and affective disorders such as major …

The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is
characterized by enhanced inflammatory activities; however, the precise pathobiology and …

Bipolar disorder (BD) is one of the most disabling diseases characterized by severe humor
fluctuation. It is accompanied by cognitive and functional impairment in addiction to high …

Microglia and brain-derived neurotrophic factor (BDNF) are essential for the neuroplasticity
that characterizes critical developmental periods. The experience-dependent development …

Increased innate immune activation and inflammation are common findings in psychotic and
affective (mood) disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major …