Progress in synthetic biology has enabled the construction of designer cells that sense
biological inputs, and, in response, activate user-defined biomolecular programs. Such …

Gene expression in mammalian cells results from coordinated protein-driven processes
guided by diverse mechanisms of regulation, including protein–protein interactions, protein …

The unfolded protein response (UPR) is a complex signal transduction pathway that
remodels gene expression in response to proteotoxic stress in the endoplasmic reticulum …

Recent progress in synthetic biology has enabled the design of complex genetic circuits that
interface with innate cellular functions, such as gene transcription, and control user-defined …

Many essential functions in biological systems, including cell cycle progression and
circadian rhythm regulation, are governed by the periodic behaviors of specific molecules …

Cell engineering presents great potential for next-generation biotechnological and
biomedical applications that employ engineered mammalian cells to sense intracellular or …

Sophisticated mechanisms controlling regulation of gene expression in mammalian cells
mediate the translation of instructions stored in the genome into molecular components that …

Cellular information processing in mammalian cells relies on sophisticated and highly
dynamic mechanisms. Unravelling these mechanisms remains a challenging endeavor and …