Basic mechanisms involved in the anti-cancer effects of melatonin

MD Mediavilla, EJ Sanchez-Barcelo… - Current medicinal …, 2010 - ingentaconnect.com
It is commonly accepted that melatonin (N-acetyl-5-methoxytryptamine), the most relevant
pineal secretory product, has oncostatic properties in a wide variety of tumors and …

Melatonin and mammary pathological growth

S Cos, EJ Sánchez-Barceló - Frontiers in neuroendocrinology, 2000 - Elsevier
In this article we review the state of the art on the role of the pineal gland and melatonin in
mammary cancer tumorigenesis in vivo as well as in vitro. The former hypothesis of a …

Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression

YW Yen, YL Lee, LY Yu, CE Li, PW Shueng… - International Journal of …, 2023 - Elsevier
Melatonin and fucoidan are naturally active compounds that have been reported to have
therapeutic benefits for patients receiving cancer treatment. However, both compounds face …

Melatonin inhibits MMP‐9 transactivation and renal cell carcinoma metastasis by suppressing Akt‐MAPKs pathway and NF‐κB DNA‐binding activity

YW Lin, LM Lee, WJ Lee, CY Chu, P Tan… - Journal of Pineal …, 2016 - Wiley Online Library
Renal cell carcinoma (RCC) is the most lethal of all urological malignancies because of its
potent metastasis potential. Melatonin exerts multiple tumor‐suppressing activities through …

Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

J Martín‐Renedo, JL Mauriz, F Jorquera… - Journal of pineal …, 2008 - Wiley Online Library
Melatonin reduces proliferation in many different cancer cell lines. However, studies on the
oncostatic effects of melatonin in the treatment of hepatocarcinoma are limited. In this study …

Inhibition of matrix metalloproteinase‐9 and nuclear factor kappa B contribute to melatonin prevention of motility and invasiveness in H ep G 2 liver cancer cells

R Ordonez, S Carbajo‐Pescador… - Journal of pineal …, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide
because of its high incidence and its metastatic potential. Extracellular matrix degradation by …

Cellular mechanisms involved in the melatonin inhibition of HT‐29 human colon cancer cell proliferation in culture

A García‐Navarro, C González‐Puga… - Journal of pineal …, 2007 - Wiley Online Library
The antiproliferative and proapoptotic properties of melatonin in human colon cancer cells in
culture were recently reported. To address the mechanisms involved in these actions, HT‐29 …

Ovarian cancer: lifestyle, diet and nutrition

A El-Sherif, S El-Sherif, AH Taylor… - Nutrition and cancer, 2021 - Taylor & Francis
Background and aims Ovarian cancer is the leading cause of female reproductive cancer
death. It is estimated that dietary habits accounts for 30% of all cancers. This review sets out …

Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor

S Carbajo‐Pescador, A García‐Palomo… - Journal of pineal …, 2011 - Wiley Online Library
Melatonin reduces proliferation in many different cancer cell lines. However, studies on the
oncostatic effects of melatonin in hepatocarcinoma are limited. We have previously …

Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts

S Chottanapund, MBM Van Duursen, P Navasumrit… - Toxicology in Vitro, 2014 - Elsevier
Targeting the estrogen pathway has been proven effective in the treatment for estrogen
receptor positive breast cancer. There are currently two common groups of anti-estrogenic …