Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Colorectal cancer (CRC) is among the most frequent forms of cancer, and new strategies for
its prevention and therapy are urgently needed. Here we identify a metabolite signalling …

The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …

The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal
proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic …

Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …