CFTR: a hub for kinases and crosstalk of cAMP and Ca2+
K Kunzelmann, A Mehta - The FEBS journal, 2013 - Wiley Online Library
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a …
(CFTR). The resulting disease is pleiotropic consistent with the idea that CFTR acts as a …
Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions
Chloride channel gating and trafficking of the cystic fibrosis transmembrane conductance
regulator (CFTR) are regulated by phosphorylation. Intrinsically disordered segments of the …
regulator (CFTR) are regulated by phosphorylation. Intrinsically disordered segments of the …
[HTML][HTML] The silent codon change I507-ATC→ ATT contributes to the severity of the ΔF508 CFTR channel dysfunction
The most common disease-causing mutation in the cystic fibrosis transmembrane
conductance regulator (CFTR) gene is the out-of-frame deletion of 3 nucleotides (CTT). This …
conductance regulator (CFTR) gene is the out-of-frame deletion of 3 nucleotides (CTT). This …
[HTML][HTML] Regulation of TMEM16A by CK2 and its role in cellular proliferation
MC Pinto, R Schreiber, J Lerias, J Ousingsawat… - Cells, 2020 - mdpi.com
Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that
forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β) …
forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β) …
[HTML][HTML] Regulatory crosstalk by protein kinases on CFTR trafficking and activity
CM Farinha, A Swiatecka-Urban, DL Brautigan… - Frontiers in …, 2016 - frontiersin.org
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a member of the ATP
binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride …
binding cassette (ABC) transporter superfamily that functions as a cAMP-activated chloride …
Positional effects of premature termination codons on the biochemical and biophysical properties of CFTR
Key points Biochemical and biophysical characterizations of three nonsense mutations of
cystic fibrosis transmembrane conductance regulator (CFTR) associated with a severe form …
cystic fibrosis transmembrane conductance regulator (CFTR) associated with a severe form …
[HTML][HTML] Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation
A Venerando, C Franchin, N Cant, G Cozza… - PloS one, 2013 - journals.plos.org
By mass spectrometry analysis of mouse Cystic Fibrosis Transmembrane-conductance
Regulator (mCFTR) expressed in yeast we have detected 21 phosphopeptides accounting …
Regulator (mCFTR) expressed in yeast we have detected 21 phosphopeptides accounting …
[HTML][HTML] Involvement of AMP-activated protein kinase (AMPK) in regulation of cell membrane potential in a gastric cancer cell line
L Zhu, X Yu, S Xing, F Jin, WJ Yang - Scientific reports, 2018 - nature.com
Membrane potential (Vmem) is a key bioelectric property of non-excitable cells that plays
important roles in regulating cell proliferation. However, the regulation of Vmem itself …
important roles in regulating cell proliferation. However, the regulation of Vmem itself …
Structural mechanisms for defective CFTR gating caused by the Q1412X mutation, a severe Class VI pathogenic mutation in cystic fibrosis
Key points Electrophysiological characterization of Q1412X‐CFTR, a C‐terminal truncation
mutation of cystic fibrosis transmembrane conductance regulator (CFTR) associated with the …
mutation of cystic fibrosis transmembrane conductance regulator (CFTR) associated with the …
[HTML][HTML] Deciphering the role of protein kinase CK2 in the maturation/stability of F508del-CFTR
C D'Amore, C Borgo, V Bosello-Travain… - … et Biophysica Acta (BBA …, 2020 - Elsevier
F508del-CFTR, the most common mutation in cystic fibrosis (CF) patients, impairs CFTR
trafficking to plasma membrane leading to its premature proteasomal degradation. Several …
trafficking to plasma membrane leading to its premature proteasomal degradation. Several …