Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …

Gene expression changes in the brain affect cognition during normal and pathological
aging. Progress in understanding the cellular processes regulating gene expression …

Extracellular signals activate mitogen-activated protein kinase (MAPK) cascades to execute
complex cellular programs, like proliferation, differentiation and apoptosis. In mammalian …

Extracellular signal-regulated kinases (Erks), members of the mitogen-activated protein
kinase superfamily, play an important role in cell proliferation and differentiation. In this study …

During the immediate-early response of mammalian cells to mitogens, histone H3 is rapidly
and transiently phosphorylated by one or more unidentified kinases. Rsk-2, a member of the …

Background Intellectual disability is a very complex condition where more than 600 genes
have been reported. Due to this extraordinary heterogeneity, a large proportion of patients …

[Frontiers in Bioscience 13, 4258-4275, May 1, 2008] 4258 The RSK factors of activating the
Ras/MAPK signaling cascade Audrey Ca Page 1 [Frontiers in Bioscience 13, 4258-4275, May …

The Ras family GTPases (Ras, Rap1, and Rap2) and their downstream mitogen-activated
protein kinases (ERK, JNK, and p38MAPK) and PI3K signaling cascades control various …

Coffin–Lowry syndrome (CLS) is a syndromic form of X-linked mental retardation, which is
characterized in male patients by psychomotor and growth retardation and various skeletal …

The Coffin-Lowry syndrome (CLS) is a rare X linked disorder in which affected males show
severe mental retardation with characteristic dysmorphism, most notably affecting the face …