D‐galactose‐induced cardiac ageing: A review of model establishment and potential interventions
S Wang, X Zhang, Z Ke, X Wen, W Li… - Journal of Cellular …, 2022 - Wiley Online Library
Cardiovascular disease (CVD) is highly prevalent in an ageing society. The increased
incidence and mortality rates of CVD are global issues endangering human health. There is …
incidence and mortality rates of CVD are global issues endangering human health. There is …
ER stress in cardiac aging, a current view on the D-galactose model
SP Alejandro - Experimental Gerontology, 2022 - Elsevier
Longitudinal studies are mandatory to study aging, however, they have certain drawbacks,
for example, they require strict maintenance that is expensive given the breeding time …
for example, they require strict maintenance that is expensive given the breeding time …
[HTML][HTML] Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway
C Li, S Jiang, H Wang, Y Wang, Y Han… - Biomedicine & …, 2022 - Elsevier
Berberine (BBR), an isoquinoline alkaloid, exerts protective effects on various cardiac
injuries, and also extends the lifespan of individuals. However, the cardioprotective effect of …
injuries, and also extends the lifespan of individuals. However, the cardioprotective effect of …
[HTML][HTML] Histone deacetylase 9 exacerbates podocyte injury in hyperhomocysteinemia through epigenetic repression of Klotho
M Liu, Y Zhang, P Zhan, W Sun, C Dong, X Liu… - Pharmacological …, 2023 - Elsevier
Although hyperhomocysteinemia (hHcys) has been recognized as an important
independent risk factor in the progression of end-stage renal disease and the development …
independent risk factor in the progression of end-stage renal disease and the development …
[HTML][HTML] Downregulation of Sirt6 by CD38 promotes cell senescence and aging
H Zhou, S Liu, NY Zhang, K Fang, J Zong, Y An… - Aging (albany …, 2022 - ncbi.nlm.nih.gov
Decreased nicotinamide adenine dinucleotide (NAD+) levels accompany aging. CD38 is the
main cellular NADase. Cyanidin-3-O-glucoside (C3G), a natural inhibitor of CD38, is a well …
main cellular NADase. Cyanidin-3-O-glucoside (C3G), a natural inhibitor of CD38, is a well …
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism …
Q Mao, M Deng, J Zhao, D Zhou, W Tong, S Xu… - Mechanisms of Ageing …, 2023 - Elsevier
Objective We aimed to evaluate the prognostic performance of circulating Klotho in coronary
atherosclerotic disease (CAD), and to further explore the effect of Klotho on stress-mediated …
atherosclerotic disease (CAD), and to further explore the effect of Klotho on stress-mediated …
Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti‐aging klotho protein in elderly mice
K Szőke, B Bódi, Z Hendrik, A Czompa… - Pharmacology …, 2023 - Wiley Online Library
Previous investigations have demonstrated that treatment of animals with rapamycin
increases levels of autophagy, which is a process by which cells degrade intracellular …
increases levels of autophagy, which is a process by which cells degrade intracellular …
[HTML][HTML] Effects of chronic kidney disease on cognitive function and α-klotho expression in hippocampus
M Huang, G Li, J Tan, M Huang, F Huang… - Translational …, 2022 - ncbi.nlm.nih.gov
Background Alpha-klotho (α-KL) is not only related to the regulation of calcium-phosphorus
metabolism, and fibrosis in chronic kidney disease (CKD), it is also involved in the regulation …
metabolism, and fibrosis in chronic kidney disease (CKD), it is also involved in the regulation …
[PDF][PDF] Recombinant Klotho protein protects pulmonary alveolar epithelial cells against sepsis-induced apoptosis by inhibiting the Bcl-2/Bax/caspase-3 pathway
XB Li, JL Liu, S Zhao, J Li, GY Zhang… - … in Clinical and …, 2024 - advances.umw.edu.pl
Background. Inflammation-induced apoptosis of alveolar type II epithelial cells is a primary
contributor to sepsis-induced acute respiratory distress syndrome (ARDS). Klotho is a single …
contributor to sepsis-induced acute respiratory distress syndrome (ARDS). Klotho is a single …
Klotho 在心力衰竭中作用的研究进展
柴亚如， 邓玉婷， 戴红艳， 管军 - 基础医学与临床, 2023 - journal11.magtechjournal.com
短篇综述Klotho在心力衰竭中作用的研究进展 Page 1 2023年6月 第43卷第6期 基础医学与
临床 Basic and Clinical Medicine June 2023 Vol.43 No.6 收稿日期:2022⁃04⁃29 修回日期:2022⁃07⁃25 …
临床 Basic and Clinical Medicine June 2023 Vol.43 No.6 收稿日期:2022⁃04⁃29 修回日期:2022⁃07⁃25 …