Mammalian target of rapamycin (mTOR) is a protein kinase involved in translation control
and long-lasting synaptic plasticity. mTOR functions as the central component of two multi …

Proper nutrition is crucial for normal brain and neurocognitive development. Failure to
optimize neurodevelopment early in life can have profound long-term implications for both …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …

Target of rapamycin (TOR) was first identified in yeast as a target molecule of rapamycin, an
anti-fugal and immunosuppressant macrolide compound. In mammals, its orthologue is …

Cells encountering hostile growth conditions, like those residing in the middle of a newly
developing solid tumor, conserve resources and energy by downregulating protein …

Recent advances in our understanding of both the regulation of components of the
translational machinery and the upstream signalling pathways that modulate them have …

Abstract Changes in gene expression are required for long-lasting synaptic plasticity and
long-term memory in both invertebrates and vertebrates. Regulation of local protein …

The translation of mRNA into polypeptides is a key step in eukaryotic gene expression.
Translation is mostly controlled at the level of initiation, which is partly regulated by the …

Despite the revolution in recent decades regarding monoamine involvement in the
management of major depressive disorder (MDD), the biological mechanisms underlying …

Activity-dependent regulation of dendritic protein synthesis is critical for enduring changes in
synaptic function, but how the unique features of distinct activity patterns are decoded by the …