Oxidative stress and reactive oxygen species: a review of their role in ocular disease

L Ung, U Pattamatta, N Carnt… - Clinical …, 2017 - portlandpress.com
For many years, oxidative stress arising from the ubiquitous production of reactive oxygen
species (ROS) has been implicated in the pathogenesis of various eye diseases. While …

Biofilms in infections of the eye

PJM Bispo, W Haas, MS Gilmore - Pathogens, 2015 - mdpi.com
The ability to form biofilms in a variety of environments is a common trait of bacteria, and
may represent one of the earliest defenses against predation. Biofilms are multicellular …

Vision defense: Efficient antibacterial AIEgens induced early immune response for bacterial endophthalmitis

T Li, Y Wu, W Cai, D Wang, C Ren, T Shen… - Advanced …, 2022 - Wiley Online Library
Bacterial endophthalmitis (BE) is an acute eye infection and potentially irreversible blinding
ocular disease. The empirical intravitreous injection of antibiotic is the primary treatment …

Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection

S Singh, PK Singh, A Jha, P Naik, J Joseph, S Giri… - Cell Reports …, 2021 - cell.com
The eye is highly susceptible to inflammation-mediated tissue damage evoked during
bacterial infection. However, mechanisms regulating inflammation to protect the eye remain …

An Eye on Staphylococcus aureus Toxins: Roles in Ocular Damage and Inflammation

R Astley, FC Miller, MH Mursalin, PS Coburn… - Toxins, 2019 - mdpi.com
Staphylococcus aureus (S. aureus) is a common pathogen of the eye, capable of infecting
external tissues such as the tear duct, conjunctiva, and the cornea, as well the inner and …

Muller glia in retinal innate immunity: a perspective on their roles in endophthalmitis

A Kumar, RK Pandey, LJ Miller… - Critical Reviews™ in …, 2013 - dl.begellhouse.com
Muller cells are the predominant glial cell type in the retina and have a unique anatomy, with
processes that span the entire retinal thickness. Although extensive morphological and …

Intravitreal injection of the chimeric phage endolysin Ply187 protects mice from Staphylococcus aureus endophthalmitis

PK Singh, DM Donovan, A Kumar - Antimicrobial agents and …, 2014 - Am Soc Microbiol
The treatment of endophthalmitis is becoming very challenging due to the emergence of
multidrug-resistant bacteria. Hence, the development of novel therapeutic alternatives for …

Gallium-Based Nanoplatform for Combating Multidrug-Resistant Pseudomonas aeruginosa and Postoperative Inflammation in Endophthalmitis Secondary to …

Y Qiao, Y Li, Y Ye, Y Yu, W Wang, K Yao… - ACS Applied Materials …, 2022 - ACS Publications
Postcataract endophthalmitis (PCE), a devastating complication following cataract surgeries,
is one of the most crucial diseases causing irreversible eye blindness. Pseudomonas …

Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure

S Emami, K Kitayama… - Cochrane Database of …, 2022 - cochranelibrary.com
Background Endophthalmitis refers to severe infection within the eye that involves the
aqueous humor or vitreous humor, or both, and that threatens vision. Most cases of …

Role of Staphylococcus aureus Virulence Factors in Inducing Inflammation and Vascular Permeability in a Mouse Model of Bacterial Endophthalmitis

A Kumar, A Kumar - PloS one, 2015 - journals.plos.org
Staphylococcus (S.) aureus is a common causative agent of bacterial endophthalmitis, a
vision threatening complication of eye surgeries. The relative contribution of S. aureus …