Despite the extensive research efforts over the past 25 years that have focused on HIV, there
is still no cure for AIDS. However, tremendous progress in the understanding of the structure …

Pharmacologic expansion of endogenous β cells is a promising therapeutic strategy for
diabetes. To elucidate the molecular pathways that control β-cell growth we screened∼ …

Objective Articular cartilage is a highly specialized tissue which forms the surfaces in
synovial joints. Full-thickness cartilage defects caused by trauma or microfracture surgery …

Immune responses to transgene products may lead to rejection of transduced cells, limiting
successful gene therapy for genetic diseases. While moderate dosages of chemotherapeutic …

Gene therapy that targets the pancreas and intestines with delivery systems using nano-
sized carriers such as viral and non-viral vectors could improve the control of blood glucose …

Although pancreatic β-cell transplantation may serve as a potential cure for diabetes mellitus
(DM), limited donor tissue availability poses a major challenge. Thus, there is a great …

We describe methods and DNA constructs/engineered mam malian promoters to enhance
native promoter activity while retaining inherent regulation by inserting multi-copy response …

1.1 Hepatocellular carcinoma 2 1.1. 1 Carcinogenesis of HCC 2 1.1. 2 Current treatment of
HCC 3 1.1. 3 Current problem of HCC treatment 6 1.1. 4 Viral gene therapy of HCC 7 1.2 …

Effective gene therapy requires regulated gene expression and vector safety. We developed
a strategy to exponentially increase native promoter activity while retaining inherent …

Abstract The incidence of Diabetes Mellitus (DM) continues to increase with approximately
7.8% of the population affected in the US alone. Although pancreatic beta cell …