Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …

Inflammatory bowel disease (IBD), a chronic inflammatory disease of the gastrointestinal
tract, is characterized by abdominal pain, diarrhea, and bloody stools, posing a serious …

Plastic particles, especially nanoplastics, represent an emerging concern of threat to human
health, oral uptake is an important pathway for the plastic particles ingestion by human …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …

Peristalsis in the digestive tract is crucial to maintain physiological functions. It remains
challenging to mimic the peristaltic microenvironment in gastrointestinal organoid culture …

The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and
spatial (re) configuration processes that culminate in human organoids in vitro generation …

Patient-derived tumor organoids have been established as promising tools for in vitro
modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are …

Airway organoids are polarized 3D epithelial structures that recapitulate the organization
and many of the key functions of the in vivo tissue. They present an attractive model that can …

In vitro tissue models hold great promise for modeling diseases and drug responses. Here,
we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet …

Primary tissue-derived epithelial organoids are a physiologically relevant in vitro intestinal
model that have been implemented for both basic research and drug development …