The shape of the force-velocity (FV) relationship has important implications for different
aspects of muscle physiology, such as muscle efficiency and fatigue, the understanding of …

In this paper we report, clarify and broaden various recent efforts to complement the
chemistry-centered models of force generation in (skeletal) muscles by mechanics-centered …

Muscle contraction and a range of critical cellular functions rely on force-producing
interactions between myosin motors and actin filaments, powered by turnover of adenosine …

In contracting muscle, individual myosin molecules function as part of a large ensemble,
hydrolyzing ATP to power the relative sliding of actin filaments. The technological advances …

Myosin II isoforms with varying mechanochemistry and filament size interact with filamentous
actin (F-actin) arrays to generate contractile forces in muscle and nonmuscle cells. How …

Myosin II is a molecular motor that converts chemical energy derived from ATP hydrolysis
into mechanical work. Myosin II isoforms are responsible for muscle contraction and a range …

Cardiac in silico numerical simulations are based on mathematical models describing the
physical processes involved in the heart function. In this review paper, we critically survey …

Muscles shorten faster against light loads than they do against heavy loads. The hyperbolic
equation first used by AV Hill over seven decades ago to illustrate the relationship between …

Hereditary hypertrophic cardiomyopathy (HCM), due to mutations in sarcomere proteins,
occurs in more than 1/500 individuals and is the leading cause of sudden cardiac death in …

Muscle contraction results from cyclic interactions between the contractile proteins myosin
and actin, driven by the turnover of adenosine triphosphate (ATP). Despite intense studies …