[HTML][HTML] Functions of oxysterol-binding proteins at membrane contact sites and their control by phosphoinositide metabolism
F Nakatsu, A Kawasaki - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Lipids must be correctly transported within the cell to the right place at the right time in order
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …
PI4KA and PIKfyve: Essential phosphoinositide signaling enzymes involved in myriad human diseases
Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …
the activity of the lipid kinases that generate phosphoinositides is causative of human …
Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4, 5-bisphosphate
Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a
crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the …
crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the …
Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity
Abstract The HRAS, NRAS, and KRAS genes are collectively mutated in a fifth of all human
cancers. These mutations render RAS GTP-bound and active, constitutively binding effector …
cancers. These mutations render RAS GTP-bound and active, constitutively binding effector …
Components of the phosphatidylserine endoplasmic reticulum to plasma membrane transport mechanism as targets for KRAS inhibition in pancreatic cancer
KRAS is mutated in 90% of human pancreatic ductal adenocarcinomas (PDACs). To
function, KRAS must localize to the plasma membrane (PM) via a C-terminal membrane …
function, KRAS must localize to the plasma membrane (PM) via a C-terminal membrane …
[HTML][HTML] Survival analysis of multi-omics data identifies potential prognostic markers of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the most common and among the deadliest of
pancreatic cancers. Its 5-year survival is only∼ 8%. Pancreatic cancers are a …
pancreatic cancers. Its 5-year survival is only∼ 8%. Pancreatic cancers are a …
The human olfactory transcriptome
Background Olfaction is a versatile sensory mechanism for detecting thousands of volatile
odorants. Although molecular basis of odorant signaling is relatively well understood …
odorants. Although molecular basis of odorant signaling is relatively well understood …
Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane
I Ulengin-Talkish, MAH Parson, ML Jenkins… - Nature …, 2021 - nature.com
Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a
critical mediator of Ca2+ signaling. Here, to discover calcineurin-regulated processes we …
critical mediator of Ca2+ signaling. Here, to discover calcineurin-regulated processes we …
Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function
WE Kattan, W Chen, X Ma, TH Lan… - Life Science …, 2019 - life-science-alliance.org
The small GTPase KRAS, which is frequently mutated in human cancers, must be localized
to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C …
to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C …
[HTML][HTML] Phosphatidylinositol 4, 5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation
The dynamic metabolism of membrane phosphoinositide lipids involves several cellular
compartments including the ER, Golgi, and plasma membrane. There are cycles of …
compartments including the ER, Golgi, and plasma membrane. There are cycles of …