Silk sericin: A versatile material for tissue engineering and drug delivery
Sericin is an inexpensive glycoprotein obtained as a by-product in the silk industry. Its
variable amino acid composition and diverse functional groups confer upon it attractive …
variable amino acid composition and diverse functional groups confer upon it attractive …
Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation
JC Stendahl, DB Kaufman, SI Stupp - Cell transplantation, 2009 - journals.sagepub.com
Intrahepatic islet transplantation provides a potentially more benign alternative to pancreatic
transplantation. However, islet transplants are associated with limited engraftment potential …
transplantation. However, islet transplants are associated with limited engraftment potential …
PDGF signalling controls age-dependent proliferation in pancreatic β-cells
H Chen, X Gu, Y Liu, J Wang, SE Wirt, R Bottino… - Nature, 2011 - nature.com
Determining the signalling pathways that direct tissue expansion is a principal goal of
regenerative biology. Vigorous pancreatic β-cell replication in juvenile mice and humans …
regenerative biology. Vigorous pancreatic β-cell replication in juvenile mice and humans …
[HTML][HTML] Synthesis of bioinspired collagen/alginate/fibrin based hydrogels for soft tissue engineering
Hydrogels based on natural polymers offer a range of properties to mimic the native
extracellular matrix, and provide microenvironments to preserve cellular function and …
extracellular matrix, and provide microenvironments to preserve cellular function and …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
Glucagon-like peptide-1 and the islet β-cell: augmentation of cell proliferation and inhibition of apoptosis
DJ Drucker - Endocrinology, 2003 - academic.oup.com
Type 2 diabetes is a heterogeneous disorder that develops as a result of relatively
inappropriate insulin secretion often in the setting of defective insulin action (insulin …
inappropriate insulin secretion often in the setting of defective insulin action (insulin …
3D bioprinting of functional islets of langerhans in an alginate/methylcellulose hydrogel blend
S Duin, K Schütz, T Ahlfeld, S Lehmann… - Advanced …, 2019 - Wiley Online Library
Transplantation of pancreatic islets is a promising strategy to alleviate the unstable blood‐
glucose control that some patients with diabetes type 1 exhibit and has seen many …
glucose control that some patients with diabetes type 1 exhibit and has seen many …
[HTML][HTML] Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective
Tremendous progress has been made over the last two decades in the field of pancreatic
beta cell replacement therapy as a curative measure for diabetes. Transplantation studies …
beta cell replacement therapy as a curative measure for diabetes. Transplantation studies …
Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel
NE Davis, LN Beenken-Rothkopf, A Mirsoian, N Kojic… - Biomaterials, 2012 - Elsevier
Pancreatic islet encapsulation within biosynthetic materials has had limited clinical success
due to loss of islet function and cell death. As an alternative encapsulation material, a silk …
due to loss of islet function and cell death. As an alternative encapsulation material, a silk …
Proliferation of sorted human and rat beta cells
Aims/hypothesis The aim of the study was to determine whether purified beta cells can
replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth …
replicate in vitro and whether this is enhanced by extracellular matrix (ECM) and growth …